Fri Oct 20 2023

28 articles - From Friday Oct 13 2023 to Friday Oct 20 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Liver Transpl

Reply: The urgent need for consensus around organ donation after assisted dying.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Effects of prenatal DHA supplementation on offspring cardiometabolic health at 11 years differs by maternal single nucleotide polymorphism rs174602: follow-up of a randomized controlled trial in Mexico.

The effect of prenatal DHA supplementation on offspring MetS score differed by maternal FADS SNP rs174602. These findings further support the need to incorporate genetic analysis of FADS polymorphisms in DHA supplementation trials. Clinical trial registry

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National Diet and Nutrition Survey data reveal a decline in folate status in the UK population between 2008 and 2019.

These data reveal a decline in population folate status in the UK between 2008 and 2019 and, a high prevalence of folate deficiency. A high proportion of FRA had RBC folate concentrations below the cut-off for increased risk of NTD. These data provide information on folate status in a population not currently exposed to mandatory folic acid fortification, and are essential to model and assess its impact.

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Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and beta-hydroxybutyrate in healthy young males.

Our investigations show that LEAP2 concentration was lower after a 36-hour fast compared with an overnight fast and that oral delivery of glucose and lactate elevated LEAP2 concentration compared with intravenous administration, whereas LEAP2 concentrations decreased with both oral and intravenous BHB. This indicates that the LEAP2 concentration is sensitive to intestinal exposure to specific substrates, highlighting the need for future studies exploring the relationship between nutrients and LEAP2.

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Inflamm Bowel Dis

Clinical and Endoscopic Outcomes Through 78 Weeks of Tofacitinib Therapy for Ulcerative Colitis in a US Cohort.

Tofacitinib treatment was effective in achieving SFCR for the majority of patients with UC through 78 weeks. Adverse events were consistent with the known safety profile of tofacitinib, and AEs requiring discontinuation were rare. Due to limitations regarding sample size, larger studies are needed to confirm these findings.

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Efficacy and Safety of Anti-Tumor Necrosis Factor Alpha in Very Early Onset Inflammatory Bowel Disease.

Efficacy and safety of anti-TNFs in VEOIBD is comparable to what has previously been reported in older patients.

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Longitudinal Trends in Pregnancy Outcomes Among Women With Inflammatory Bowel Disease in the Era of Biologics: A 20-Year Nationwide Analysis.

Trends in pregnancy outcomes have followed a similar trajectory in patients with and without IBD. However, there is still demonstrable risk of adverse pregnancy outcomes in patients with IBD.

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Plasma Extracellular Vesicle LncRNA H19 as a Potential Diagnostic Biomarker for Inflammatory Bowel Diseases.

Our study suggests that circulating EV-lncRNA H19 exhibited promising potential for the diagnosis of active IBD.

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Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.

The clinical effects of vedolizumab reveal integrin a4ß7-dependent dendritic cell migration to the intestinal mucosa to be central to inflammatory bowel disease pathogenesis.

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J Crohns Colitis

Does KONO-S anastomosis reduce recurrence in Crohn's disease compared to conventional ileocolonic anastomosis? A nationwide propensity score-matched study from GETAID Chirurgie Group (KoCoRICCO study).

The KoCoRICCO study suggests that Kono-S anastomosis does not reduce the risk of endoscopic recurrence in Crohn's disease compared to conventional side-to-side anastomosis. Further research with a longer follow-up is necessary to determine whether there is a potential benefit on surgical recurrence.

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Janus kinase inhibitors differentially inhibit specific cytokine signals in the mesenteric lymph node cells of IBD patients.

Despite their similarities, differences exist in the relative potencies of different JAKinibs against distinct cytokine families to explain their clinical efficacy.

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Lymphoma In Patients With Inflammatory Bowel Disease: A Multicenter Collaborative Study Between Getaid And Lysa.

Lymphomas occurring in IBD patients do not seem to have a worse outcome than in patients without IBD. Due to the scarcity of this situation, those patients should be managed in expert centers.

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Validation of the pharmacokinetic model for anti- TNFa clearance in infants exposed to anti- TNFa during pregnancy.

The validity of the anti-TNFa clearance model is high, and hence can be used to guide clinicians regarding timing of live vaccines in infants exposed to adalimumab or infliximab in utero.

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Pancreas

Geriatric Nutritional Risk Index Predicts Tolerability of S-1 as Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma.

High GNRI value is a predictive marker for the completion of S-1 as AC for PDAC.

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Historical Review of Acute Pancreatitis Research Over the Last 80 Years.

Over the past 80 years, the pathogenesis, treatment, risk management, and experimental model were the main research highlights. Optimal supportive management, minimally invasive treatment, and prediction of prognosis are subjects of interest for clinical practitioners; signal transduction to identify a target for precise treatment is the focus of experimental research in AP.

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Pancreatology

External validation of scores predicting postoperative fistula after pancreatogastrostomy for pancreatoduodenectomy reconstruction. A single center experience.

Our study including exclusively pancreatogastrostomies failed to validate the most used predictive scores for POPF. We found that only male gender and soft pancreatic texture are associated with POPF. Specific predictive scores following pancreatogasgtrostomy are needed.

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Incident diabetes following acute pancreatitis in a multicenter prospective observational cohort.

Larger prospective studies are needed to further define the incidence, risk factors, and mechanisms of diabetes and pre-diabetes following AP. NCT03063398.

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Macroscopic qualitative evaluation of solid pancreatic lesion specimens from endoscopic ultrasound-guided fine needle aspiration/biopsies.

Macroscopic evaluations of EUS-FNA/B can enable the identification of specimen components and a possible diagnosis. They also contribute to the selection of the optimal tissue-handling methods.

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No role for protease inhibitors as a mitigation strategy for postpancreatectomy acute pancreatitis (PPAP): Propensity score matching analysis.

No difference in intravenous crystalloid administration was found in patients with PPAP, whether or not they developed major complications or pancreatic fistula (p > 0.05) CONCLUSION: Protease inhibitor seems ineffective in preventing a PPAP after PD once a POH has occurred. Further studies are needed to achieve benchmarks for treating PPAP and identify mitigation strategies to prevent the evolution of POH into additional morbidity.

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Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: Prognostic role of ABCC8.

The study shows for the first time that the cytoplasmic ABCC8 protein expression has prognostic value in PDAC.

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Trends and clinical characteristics of pediatric acute pancreatitis patients in Japan: A comparison with adult cases based on a national administrative inpatient database.

There was an upward trend in the proportion of AP among al admissions in pediatrics, with a lower risk of complications and mortality than adult cases.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

New insights into mechanisms of vitamin B12 uptake and conversion.

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J Crohns Colitis

Adalimumab: A 'Maillon Faible' in the Treatment of Ulcerative Colitis?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

At-home Disease Monitoring by Patient-performed Intestinal Ultrasound in Severe Ulcerative Colitis.

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Liver Transpl

Management of patients with cirrhosis in the emergency department: Implications for hospitalization outcomes.

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Pancreas

Design Flaws in Study of Prophylaxis of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis.

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Memorial Tribute to Paul D. Webster, III, MD.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Association analysis of CUZD1 variants in European chronic pancreatitis patients.

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